Peer-reviewed scientific articles and publications from our research and industry partners offering insights, data and more.
Elomaa, A.P., Lehtonen, S.J.R., Vik-Mo, E., Charbel, F.T., von und zu Fraunberg, M., Visuri, M., Luoma, J., Kelahaara, M., Haapala, I., Huotarinen, A., Rantala, S., Konki, J., Leskinen, J., Semenov, D., Haapasalo, J., Puustinen, S. Intraoperative 5-ALA fluorescence-guided aspirate tissue monitoring in high-grade glioma surgery: the first-in-human study on clinical performance and safety. Neuro-Oncology Advances, 2026.
https://doi.org/10.1093/noajnl/vdag029
Elomaa, A.P., Lehtonen, S.J.R., von und zu Fraunberg, M., Charbel, F., Luoma, J., Visuri, M., Haapala, I., Haapasalo, J., Vik-Mo, E., Puustinen, S. P14.15.A INTRAOPERATIVE ASPIRATE TISSUE MONITORING DURING 5-ALA GUIDED HIGH-GRADE GLIOMA SURGERY. Neuro-Oncology, 2024, Vol. 26 (Supplement 5), v80-v81. https://doi.org/10.1093/neuonc/noae144.266.
Elomaa, A.P., Lehtonen, S.J.R., Leskinen, J., Semenov, D. Intraoperative aspirate tissue monitoring during 5-ALA fluorescence-guided surgery of high-grade glioma – the first-in-human observational cases. Brain and Spine 2023, 3, 102121, doi:10.1016/j.bas.2023.102121.
Our clinical research demonstrates that the HIVEN® device increases the detection of fluorescence during surgery [1]. Fluorescence detection has been shown to lead to more complete tumour resection and improved progression-free survival. According to experts, the aspirate tissue monitoring technique using HIVEN® provides supplementary information on tissue fluorescence for surgeons [2, 3] and 483% more information in comparison to visual fluorescence guidance [4].
[1] Marginum Ltd. Internal Clinical Evaluation Report, 2025.
[2] A Elomaa, S Lehtonen, M von und zu Fraunberg, F Charbel, J Luoma, M Visuri, I Haapala, J Haapasalo, E Vik-Mo, S Puustinen, P14.15.A INTRAOPERATIVE ASPIRATE TISSUE MONITORING DURING 5-ALA GUIDED HIGH-GRADE GLIOMA SURGERY, Neuro-Oncology, Volume 26, Issue Supplement_5, October 2024, Pages v80–v81, https://doi.org/10.1093/neuonc/noae144.266
[3] A Elomaa, S Lehtonen, J Leskinen, D Semenov. Intraoperative aspirate tissue monitoring during 5-ALA fluorescence-guided surgery of high-grade glioma – the first-in-human observational cases. Brain and Spine 2023, 3, 102121, https://doi.org/10.1016/j.bas.2023.102121
[4] A Elomaa, S Lehtonen, E Vik-Mo, F Charbel, M von und zu Fraunberg, M Visuri, J Luoma, M Kelahaara, I Haapala, A Huotarinen, S Rantala, J Konki, J Leskinen, D Semenov, J Haapasalo, S Puustinen. Intraoperative 5-ALA fluorescence-guided aspirate tissue monitoring in high-grade glioma surgery: the first-in-human study on clinical performance and safety. Neuro-Oncology Advances, 2026. https://doi.org/10.1093/noajnl/vdag029